Day

January 18, 2018
ACOMP

Monitoring Methyl Methacrylate: ACOMP Application Note 002

Monitoring the polymerization of methyl methacrylate (MMA) in the presence and absence of crosslinker ACOMP is used to measure polymer properties in realtime ACOMP is an online monitoring system that continuously analyzes polymer properties during production in realtime. ACOMP uses a well-known, non-chromatographic technique to measure monomer and polymer concentration, intrinsic viscosity and weight average...
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ARGEN_PEGS Boston 2018

Determining Mw and B22 of mAbs: ARGEN Application Note 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN_PEGS Boston 2018

Formulation Development: ARGEN Application Note 002

Formulation Development with ARGEN Abstract Formulations are developed in the biopharmaceutical space as a set of solution conditions that lead to the highest stability of a therapeutic substance such as an antibody protein or peptide.  The solution conditions that generally affect the stability of the solute are solvent choice, ionic strength, pH, excipient, surfactant and...
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ARGEN

Comparing Protein Stability: ARGEN Application Note 001

Comparing the Stability of Protein Formulations with ARGEN   Abstract Biopharmaceutical companies isolate many types of proteins for use in experimental and therapeutic medicines. Unfortunately, when  removed from their native environments, proteins become less stable. Unstable proteins are more prone to degradation from the primary stress mechanisms: mechanical and thermal (from manufacturing, storage and transport) and...
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