Day

January 18, 2018

Monitoring the Polymerization of Polymethylmethacrylate

The polymerization of PMMA can occur through various methods, including in liquid-phase solution, in a bulk extrusion process, and via casting. ACOMP is an online, smart manufacturing system that continuously monitors polymer properties in real time. This technical note illustrates how ACOMP can successfully monitor and characterize the solution polymerization of PMMA in the presence...
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Rapid Determination of Mw for a Monoclonal Antibody

Colloidal stability is determined by the balance of repulsive and attractive intermolecular interactions between protein molecules, like a monoclonal antibody, to conserve the native folded state. Simply stated, the propensity for aggregation is reduced by less intermolecular interaction. Therefore, determination of the second virial coefficient (B22) is a valuable screening tool to predict aggregation propensity....
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Kinetic Analysis of Protein Stability & Oligomeric State Transitions of Human Insulin

These experiments demonstrate the utility of ARGEN™ to define oligomeric states and transitions of Human Insulin under thermal stress. Time to dimerization and time to tetramerization measurements permitted the characterization of a stable dimer species, as well as insights into the mechanisms and kinetics of higher order oligomer formation. Whereas, SEC allows the characterization of...
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