Biologics stability testing has traditionally been a slow process; however, real-time monitoring tools now enable teams to access more information faster. As real-time technologies become more accessible, the industry is shifting toward faster, more reliable workflows. By replacing long stability studies with immediate feedback, biopharmaceutical companies can reduce risks, shorten...Read More
In the rapidly evolving world of biopharmaceutical research, the search to optimize formulation development efforts and understand peptide stability has taken center stage. With a myriad of applications ranging from the treatment of diseases to novel delivery systems, the potential of peptides is vast. Read More
In the high-stakes realm of biopharmaceutical research and development, understanding antibody stability is very important. Antibody stability is a multi-faceted concern that includes aspects of aggregation, degradation, and conformational integrity. Each of these potential problems can negatively impact antibody stability and the performance and manufacturability of biotherapeutics.Read More
In the realm of biopharmaceuticals, custom peptide and oligonucleotide development has opened new horizons for targeted therapeutic interventions. However, the success of peptide and oligonucleotide development hinges significantly on a comprehensive understanding of their stability. However, biopharma teams using ARGEN can access real-time stability insights as they develop peptide, oligonucleotide,...Read More
Recent research on stress factors in monoclonal antibody development underscores the critical need for robust control strategies in monoclonal antibody drug substance production, focusing on the risks posed by various stress conditions during manufacturing. These stressors can lead to protein modifications, impacting both patient safety and product quality. ARGEN, by...Read More
The academic research partner of Yokogawa Fluence Analytics, Tulane PolyRMC, partnered with Spark Therapeutics on a new peer-reviewed article in Biomacromolecules that highlights the degradation of adeno-associated virus (AAV) under moderate thermal stress (30−53°C) and in physiological solution (pH7.2, 180 mM NaCl). Read More
Characterizing colloidal stability is central to developing safe and efficacious protein-based therapeutics. To be viable, the target biotherapeutic must remain stable during production, storage, and patient delivery. The most insightful and successful techniques for monitoring and characterizing colloidal stability involve in-situ and real time analysis under modelled stress conditions. This...Read More
This article provides a high-level comparison of light scattering techniques, including similarities and differences between them in biopharma applications.Read More
