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Application Notes
ACOMP

Application Note: ACOMP 002

Monitoring the polymerization of methyl methacrylate (MMA) in the presence and absence of crosslinker ACOMP is used to measure polymer properties in realtime ACOMP is an online monitoring system that continuously analyzes polymer properties during production in realtime. ACOMP uses a well-known, non-chromatographic technique to measure monomer and polymer concentration, intrinsic viscosity and weight average...
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ARGEN

Application Note: ARGEN 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN

Application Note: ARGEN 002

Formulation Development with ARGEN Abstract Formulations are developed in the biopharmaceutical space as a set of solution conditions that lead to the highest stability of a therapeutic substance such as an antibody protein or peptide.  The solution conditions that generally affect the stability of the solute are solvent choice, ionic strength, pH, excipient, surfactant and...
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ARGEN

Application Note: ARGEN 001

Comparing the Stability of Protein Formulations with ARGEN Abstract Because ARGEN’s 16 experiments are fully independent, users can determine aggregation or degradation characteristics of protein formulations for all samples simultaneously, regardless of their individual time spans (some can take minutes, others can take weeks). When one sample is complete, another can immediately take its place....
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ACOMP

Application Note: ACOMP 001

Monitoring the effect of initiator concentration on molecular weight and intrinsic viscosity of polyvinyl pyrrolidone (PVP) using ACOMP Abstract Automatic Continuous Online Monitoring of Polymerization Reactions (ACOMP) was used to monitor the free radical polymerization of polyvinyl pyrrolidone (PVP) throughout the reaction. Two batch reactions were run at 1.5% and 2.5% initiator concentration to monitor...
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