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ARGEN_PEGS Boston 2018

Application Note: ARGEN 005

Formulation of Four Peptide Solutions in 15 Days Background Custom designed oligopeptides are an increasingly accessible option in peptide-based technologies for pharmaceuticals. Following their synthesis, peptides are often subjected to HPLC purification and synthetic modification, which can require the use of non-aqueous media or salts requiring later removal. During the production of pharmaceutical peptides, spoilage...
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Fluence Analytics - New website

Fluence Analytics Brochure

Fluence Analytics Brochure: realtime data. realtime optimization. Fluence Analytics is a manufacturer of industrial and laboratory monitoring solutions that produce continuous data streams. The company has two product lines, ACOMP and ARGEN. Combined with powerful, proprietary analytical tools, the confluence of data from the company’s measurements enable realtime optimization leading to improved process control and faster R&D for polymer and biopharmaceutical manufacturers....
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 004

Kinetic Analysis of Peptide Aggregation Background Peptide-based pharmaceutical technology requires the delivery of therapeutic oligopeptides as designed in a stable form for effective application. Downstream from therapeutic peptide isolation or synthesis, peptides are often subjected to HPLC purification, synthetic modification, and preparatory treatments for long-term storage. Spoilage in the form of aggregation, degradation or oxidation...
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FA_Product_ACOMP

Case Study: ACOMP 001

Global Specialty Polymer Manufacturer using ACOMP to Monitor Realtime Monomer Conversion Attains 17% Cycle Time Reduction Background A global specialty chemical company produces high-value polymer products in batch reactions. Prior to ACOMP, the process and quality control procedure was to manually pull samples from the reactor for laboratory characterization of polymer properties such as molecular...
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FA_Product_ACOMP

Application Note: ACOMP 002

Monitoring the polymerization of methyl methacrylate (MMA) in the presence and absence of crosslinker ACOMP is used to measure polymer properties in realtime ACOMP is an online monitoring system that continuously analyzes polymer properties during production in realtime. ACOMP uses a well-known, non-chromatographic technique to measure monomer and polymer concentration, intrinsic viscosity and weight average...
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 002

Formulation Development with ARGEN Abstract Formulations are developed in the biopharmaceutical space as a set of solution conditions that lead to the highest stability of a therapeutic substance such as an antibody protein or peptide.  The solution conditions that generally affect the stability of the solute are solvent choice, ionic strength, pH, excipient, surfactant and...
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FA_Product_ARGEN

Application Note: ARGEN 001

Comparing the Stability of Protein Formulations with ARGEN Abstract Because ARGEN’s 16 experiments are fully independent, users can determine aggregation or degradation characteristics of protein formulations for all samples simultaneously, regardless of their individual time spans (some can take minutes, others can take weeks). When one sample is complete, another can immediately take its place....
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ARGEN_PEGS Boston 2018

Technical Note: ARGEN 002

Generating Aggregation Rates to Determine Stability of Monoclonal Antibodies Background Static light scattering is widely used to measure the molar masses of molecules, particles and their aggregates under various solution conditions and compositions1. The ARGEN instrument has the capability to run 16 independent light scattering experiments simultaneously. It can monitor the change in both absolute...
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ARGEN_PEGS Boston 2018

Technical Note: ARGEN 001

ARGEN: The Aggregation Rate GENerator that monitors protein and polymer stability Summary Fluence Analytics ARGEN platform continuously measures the light scattering from 16 independent solutions to assess the pharmaceutical stability of therapeutic proteins and natural polymers. ARGEN applies temperature and stirring stressors independently to each of the 16 sample cells, replicating the conditions of and...
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