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ACOMP

Monitoring Pressure Sensitive Adhesives: ACOMP Application Note 003

ACOMP Monitors 2-Ethylhexyl Acrylate and its comonomer based reactions Background The history of pressure-sensitive adhesive (PSA) dates back to the 1920s. Since PSAs are critical to the medical, engineering and construction industries, the demand for the adhesive is still growing. As reported by Tom Brown Inc.[4], the demand for pressure sensitive adhesive tape in 2017...
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ARGEN_PEGS Boston 2018

Impact of Stirring Stress: ARGEN Technical Note 004

Using ARGEN to Determine the Impact of Mechanical and Physical Stress   Curt Jarand, Ph.D. Tulane University Center for Polymer Reaction Monitoring and Characterization (PolyRMC) New Orleans, LA 70118   The Stirring Problem: There is intense interest among therapeutic protein researchers about factors which impact protein aggregation and stability. Aggregation of therapeutic proteins can render...
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ARGEN_PEGS Boston 2018

Using 90° SLS to Determine Mw: ARGEN Technical Note 003

On the limits of 90° static light scattering for determining weight average molar mass Mw – A discussion with Chief Science Officer, Dr. Wayne Reed Technical Note 003 assesses the fractional error in Mw that results when θ=90° detection is used, instead of a full angular extrapolation via MALS.   Question: Can you compare the differences in...
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ARGEN_PEGS Boston 2018

Formulating Four Peptides: ARGEN Application Note 005

Formulation of Four Peptide Solutions in 15 Days Background Custom designed oligopeptides are an increasingly accessible option in peptide-based technologies for pharmaceuticals. Following their synthesis, peptides are often subjected to HPLC purification and synthetic modification, which can require the use of non-aqueous media or salts requiring later removal. During the production of pharmaceutical peptides, spoilage...
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Fluence Analytics - New website

Fluence Analytics Brochure

Fluence Analytics Brochure: realtime data. realtime optimization. Fluence Analytics is a manufacturer of industrial and laboratory monitoring solutions that produce continuous data streams. The company has two product lines, ACOMP and ARGEN. Combined with powerful, proprietary analytical tools, the confluence of data from the company’s measurements enable realtime optimization leading to improved process control and faster R&D for polymer and biopharmaceutical manufacturers....
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ARGEN_PEGS Boston 2018

Kinetic Analysis of Peptide Aggregation: ARGEN Application Note 004

Kinetic Analysis of Peptide Aggregation Background Peptide-based pharmaceutical technology requires the delivery of therapeutic oligopeptides as designed in a stable form for effective application. Downstream from therapeutic peptide isolation or synthesis, peptides are often subjected to HPLC purification, synthetic modification, and preparatory treatments for long-term storage. Spoilage in the form of aggregation, degradation or oxidation...
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ACOMP

Case Study: ACOMP 001

Global Specialty Polymer Manufacturer using ACOMP to Monitor Realtime Monomer Conversion Attains 17% Cycle Time Reduction Background A global specialty chemical company produces high-value polymer products in batch reactions. Prior to ACOMP, the process and quality control procedure was to manually pull samples from the reactor for laboratory characterization of polymer properties such as molecular...
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ACOMP

Monitoring Methyl Methacrylate: ACOMP Application Note 002

Monitoring the polymerization of methyl methacrylate (MMA) in the presence and absence of crosslinker ACOMP is used to measure polymer properties in realtime ACOMP is an online monitoring system that continuously analyzes polymer properties during production in realtime. ACOMP uses a well-known, non-chromatographic technique to measure monomer and polymer concentration, intrinsic viscosity and weight average...
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ARGEN_PEGS Boston 2018

Determining Mw and B22 of mAbs: ARGEN Application Note 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN_PEGS Boston 2018

Formulation Development: ARGEN Application Note 002

Formulation Development with ARGEN Abstract Formulations are developed in the biopharmaceutical space as a set of solution conditions that lead to the highest stability of a therapeutic substance such as an antibody protein or peptide.  The solution conditions that generally affect the stability of the solute are solvent choice, ionic strength, pH, excipient, surfactant and...
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