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FA_Product_ACOMP

Case Study: ACOMP 001

Global Specialty Polymer Manufacturer using ACOMP to Monitor Realtime Monomer Conversion Attains 17% Cycle Time Reduction Background A global specialty chemical company produces high-value polymer products in batch reactions. Prior to ACOMP, the process and quality control procedure was to manually pull samples from the reactor for laboratory characterization of polymer properties such as molecular...
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FA_Product_ACOMP

Application Note: ACOMP 002

Monitoring the polymerization of methyl methacrylate (MMA) in the presence and absence of crosslinker ACOMP is used to measure polymer properties in realtime ACOMP is an online monitoring system that continuously analyzes polymer properties during production in realtime. ACOMP uses a well-known, non-chromatographic technique to measure monomer and polymer concentration, intrinsic viscosity and weight average...
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 002

Formulation Development with ARGEN Abstract Formulations are developed in the biopharmaceutical space as a set of solution conditions that lead to the highest stability of a therapeutic substance such as an antibody protein or peptide.  The solution conditions that generally affect the stability of the solute are solvent choice, ionic strength, pH, excipient, surfactant and...
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 001

Comparing the Stability of Protein Formulations with ARGEN Abstract Because ARGEN’s 16 experiments are fully independent, users can determine aggregation or degradation characteristics of protein formulations for all samples simultaneously, regardless of their individual time spans (some can take minutes, others can take weeks). When one sample is complete, another can immediately take its place....
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ARGEN_PEGS Boston 2018

Technical Note: ARGEN 002

Generating Aggregation Rates to Determine Stability of Monoclonal Antibodies Background Static light scattering is widely used to measure the molar masses of molecules, particles and their aggregates under various solution conditions and compositions1. The ARGEN instrument has the capability to run 16 independent light scattering experiments simultaneously. It can monitor the change in both absolute...
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ARGEN_PEGS Boston 2018

Technical Note: ARGEN 001

ARGEN: The Aggregation Rate GENerator that monitors protein and polymer stability Summary Fluence Analytics ARGEN platform continuously measures the light scattering from 16 independent solutions to assess the pharmaceutical stability of therapeutic proteins and natural polymers. ARGEN applies temperature and stirring stressors independently to each of the 16 sample cells, replicating the conditions of and...
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ACOMP

Application Note: ACOMP 001

Monitoring the effect of initiator concentration on molecular weight and intrinsic viscosity of polyvinyl pyrrolidone (PVP) using ACOMP Abstract Automatic Continuous Online Monitoring of Polymerization Reactions (ACOMP) was used to monitor the free radical polymerization of polyvinyl pyrrolidone (PVP) throughout the reaction. Two batch reactions were run at 1.5% and 2.5% initiator concentration to monitor...
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FA_Product_ACOMP

ACOMP Brochure

Realtime Monitoring of Polymerization Reactions ACOMP is Automatic Continuous On-line Monitoring of Polymerization reactions, a patented solution that continuously extracts, dilutes, and conditions a small stream of reactor contents for analysis by a variety of non-chromatographic and chromatographic methods throughout the entire reaction process. The system can directly measure macromolecular properties during production. This fundamental information is used...
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ARGEN_PEGS Boston 2018

ARGEN Brochure

Protein Stability Monitoring ARGEN by Fluence Analytics is the right instrument to assess the pharmaceutical stability of therapeutic proteins and general stability of natural polymer products. ARGEN allows for 16 independent experiments to run simultaneously, and each sample is measured continuously throughout the experiment, yielding extremely valuable kinetic sample stability data. ARGEN utilizes 16 completely independent cuvette sample holders, and...
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