ACOMP was used to continuously measure the anionic polymerization of solution styrene butadiene rubber. ACOMP successfully tracked conversion, along with weight-average molecular weight (Mw), and low and high shear reduced viscosities (RV), including during the coupling reaction.Read More
This technical note describes the use of ACOMP to monitor polymerization kinetics, intrinsic viscosity and Mw in a very common system for producing pressure sensitive adhesives, which uses the acrylic comonomers acrylic acid (AA) and 2-ethylhexyl acrylate (2EHA).Read More
The successful development of biotherapeutics requires an in-depth understanding of the impacts associated with mechanical and physical stress. Instability and subsequent aggregation can render them biologically inactive or even induce an immunological response in patients. Stirring stress is one of the most notable factors which disrupts native biopolymer structure and promotes aggregation. However, contact stirring...Read More
On the limits of 90° static light scattering for determining weight average molar mass Mw A discussion with Chief Science Officer, Dr. Wayne Reed This Technical Note assesses the fractional error in Mw that results when θ=90° static light scattering detection is used, instead of a full angular extrapolation via MALS. Read More
Fluence Analytics Brochure: realtime data. realtime optimization. Fluence Analytics is a manufacturer of industrial and laboratory monitoring solutions that produce continuous data streams. The company has two product lines, ACOMP and ARGEN. Combined with powerful, proprietary analytical tools, the confluence of data from the company’s measurements enable realtime optimization leading to improved process control and...Read More
The polymerization of PMMA can occur through various methods, including in liquid-phase solution, in a bulk extrusion process, and via casting. ACOMP is an online, smart manufacturing system that continuously monitors polymer properties in real time. This technical note illustrates how ACOMP can successfully monitor and characterize the solution polymerization of PMMA in the presence...Read More
Colloidal stability is determined by the balance of repulsive and attractive intermolecular interactions between protein molecules, like a monoclonal antibody, to conserve the native folded state. Simply stated, the propensity for aggregation is reduced by less intermolecular interaction. Therefore, determination of the second virial coefficient (B22) is a valuable screening tool to predict aggregation propensity....Read More
These experiments demonstrate the utility of ARGEN™ to define oligomeric states and transitions of Human Insulin under thermal stress. Time to dimerization and time to tetramerization measurements permitted the characterization of a stable dimer species, as well as insights into the mechanisms and kinetics of higher order oligomer formation. Whereas, SEC allows the characterization of...Read More
In these experiments, ARGEN was used to characterize the thermal and chemical stability of a monoclonal antibody and subsequently establish quantitative and qualitative properties such as pH and temperature dependence on aggregation kinetics. Additionally, SEC elution profiles were superimposed onto Mw/Mo output, providing a robust comparison and identification of the stability landscape for the mAb....Read More
Understanding the thermal, chemical and mechanical stability and physical properties of polymers is essential for development success. The case studies below outline the experimental methodologies and data analysis using ARGEN™ to monitor polymer degradation and to characterize molecular weight as well as the effects of temperature, shear stress and solution conditions on the stability of...Read More
