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Publications

Modeling of an Oxygen Threshold in Aqueous Free Radical and RAFT Polymerization Reactions

Fluence Analytics recently teamed up with its academic research partner, Tulane PolyRMC, to investigate the complex role that oxygen (O2) plays during both free and controlled radical polymerization reactions in an aqueous medium with ACOMP.
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FTIR Detector Used to Identify Comonomers with Similar UV Spectra

Tulane PolyRMC, the academic research partner of Fluence Analytics, recently published a peer-reviewed article for Macromolecular Reaction Engineering that details the use of ACOMP, coupled with an FTIR (Fourier-transform infrared spectroscopy) detector, to continuously monitor and characterize a copolymerization reaction of acrylate monomers with an indistinguishable UV spectra. Typically for ACOMP applications, a UV detector...
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Kinetic analysis of RAFT and free radical copolymerization

Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Polymer Journal which describes the kinetic analysis of continuous reaction data for RAFT and free radical copolymerization with acrylic and styrenic monomers. Free radical and RAFT copolymerization rates for styrenic monomers in bulk and aqueous reactions were accelerated by...
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Online Monitoring of Terpolymerization Reaction with an NMR Coupled to ACOMP

Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Macromolecular Reaction Engineering which describes the successful online monitoring of the terpolymerization reaction of acrylamide, sodium acrylate, and styrene sulfonate. The terpolymerization reaction was monitored by coupling a nuclear magnetic resonance (NMR) detector to ACOMP. The NMR detector was...
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Reproducibility of Thermally Induced and Contact-stir Induced Protein Aggregation

This peer-reviewed publication by Fluence Analytics’ research partner Tulane PolyRMC addresses the reproducibility of protein aggregation. The publication, which appears in the Journal of Physical Chemistry, specifically discusses reproducibility following temperature-induced and contact-stir induced aggregation of bovine serum albumin and a monoclonal antibody. Using ARGEN, PolyRMC assessed protein aggregation reproducibility for global stressors which affect an...
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Automatic Control of Polymer Composition and Mw

Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Polymer Journal which describes the achievement of fully automatic, simultaneous control of polymer composition and molecular weight trajectories during free radical copolymer synthesis. This was accomplished by coupling the continuous ACOMP data stream into a feedback controller which operated pumps for...
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Automated & Rapid Way to Assess Quality & Stability of Biologics

Determine the Stability of Biologics This peer review article from American Pharmaceutical Review describes new tools for determining the stability of biologics, including ARGEN by Fluence Analytics, that not only have low sample requirements but also generate precise and reproducible data to effectively implement an advanced design of experiments approach. This article uses a real case...
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Automatic Synthesis of Multimodal Polymers

Fluence Analytics collaborated with its academic research partner Tulane PolyRMC on a peer review publication in Macromolecular Reaction Engineering. An automatic molecular weight controller is used in semi-batch reactions to produce multimodal polymers that contain distinct subpopulations with different molecular weight distributions (MWD). While blending polymers with different MWD is frequently used to make products from...
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Automatic Control of Polymer Molecular Weight during Synthesis

Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Macromolecules which discusses using ACOMP to automatically control polymer molecular weight during synthesis. The continuous record of monomer and polymer concentrations, Cm and Cp, and cumulative weight-average mass, Mw, furnished by automatic continuous online monitoring of polymerization reactions (ACOMP) has been harnessed...
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