Category

Technical Notes
ARGEN_PEGS Boston 2018

Impact of Stirring Stress: ARGEN Technical Note 004

Using ARGEN to Determine the Impact of Mechanical and Physical Stress   Curt Jarand, Ph.D. Tulane University Center for Polymer Reaction Monitoring and Characterization (PolyRMC) New Orleans, LA 70118   The Stirring Problem: There is intense interest among therapeutic protein researchers about factors which impact protein aggregation and stability. Aggregation of therapeutic proteins can render...
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ARGEN_PEGS Boston 2018

Using 90° SLS to Determine Mw: ARGEN Technical Note 003

On the limits of 90° static light scattering for determining weight average molar mass Mw – A discussion with Chief Science Officer, Dr. Wayne Reed Technical Note 003 assesses the fractional error in Mw that results when θ=90° detection is used, instead of a full angular extrapolation via MALS.   Question: Can you compare the differences in...
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ARGEN_PEGS Boston 2018

Generating Aggregation Rates: ARGEN Technical Note 002

Generating Aggregation Rates to Determine Stability of Monoclonal Antibodies Background Static light scattering is widely used to measure the molar masses of molecules, particles and their aggregates under various solution conditions and compositions1. The ARGEN instrument has the capability to run 16 independent light scattering experiments simultaneously. It can monitor the change in both absolute...
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ARGEN_PEGS Boston 2018

Introduction to ARGEN: Technical Note 001

ARGEN: The Aggregation Rate GENerator that monitors protein and polymer stability Summary Fluence Analytics ARGEN platform continuously measures the light scattering from 16 independent solutions to assess the pharmaceutical stability of therapeutic proteins and natural polymers. ARGEN applies temperature and stirring stressors independently to each of the 16 sample cells, replicating the conditions of and...
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ACOMP

Introduction to ACOMP: Technical Note 001

ACOMP: The Automated System that allows Continuous Realtime Monitoring of Polymerization Reactions Abstract ​ ACOMP (Automatic Continuous Online Monitoring of Polymerization Reactions) is a patented product from Fluence Analytics that continuously monitors and characterizes polymers during polymerization or post-polymerization processing steps of laboratory or industrial scale polymer reactions. Beyond allowing the user to monitor polymerizations...
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