Advancing Custom Peptide and Oligonucleotide Development

 

In the realm of biopharmaceuticals, custom peptide and oligonucleotide development has opened new horizons for targeted therapeutic interventions. However, the success of peptide and oligonucleotide development hinges significantly on a comprehensive understanding of their stability. The good news is that biopharma teams using ARGEN can access real-time stability insights as they develop peptide, oligonucleotide, and protein-based therapeutics.

Real-time Monitoring and Rapid Characterization

ARGEN is a lab instrument that rapidly characterizes biopolymer stability with an in-situ, real-time monitoring capability. This is critical for formulation development teams and allows them to immediately understand how custom peptides and oligonucleotides behave under various production conditions.

Understanding Oligomeric State Transitions: The kinetics of oligomeric state transitions are pivotal in understanding the molecular stability during peptide and oligonucleotide development. ARGEN facilitates a visualization of these transitions, for instance, from monomer to dimer or higher order species, under defined conditions.

Modeling Bioprocessing Stress Conditions: ARGEN’s design permits the modelling of various stress conditions encountered during bioprocessing, such as chemical, mechanical (shear), and thermal stress. This is vital for optimizing the purification, storage, and formulation processes, ensuring the longevity and efficacy of custom peptides and oligonucleotides.

Parallel Multi-Sample Analysis: The ability to analyze up to 16 independently controlled sample cells in parallel significantly accelerates the data collection process. By employing a Design of Experiment (DOE) format, ARGEN allows for an extensive exploration of stability parameters across a large spectrum of samples. This has proven to expedite the formulation development pathway to identify the optimal candidate.

Shelf-Life Stability Studies: Establishing and optimizing shelf-life, especially at low temperatures, is a significant advantage provided by ARGEN. This feature is crucial for biopharmaceutical companies aiming to ensure the extended stability and viability of their custom peptides and oligonucleotides.

Orthogonal Technique Integration: Data generated using ARGEN can be coupled with orthogonal techniques, such as SEC, Native Polyacrylamide Gel Electrophoresis (PAGE), Dynamic Light Scattering (DLS), and Raman spectroscopy. This integrated approach provides a holistic understanding of stability, bolstering the confidence in product quality and consistency.

Connect with Yokogawa Fluence Analytics Today!