New Study Involves Increased Protein Stability Using APMT’s ARGEN Product
(New Orleans, LA, U.S.) ‒ Advanced Polymer Monitoring Technologies (APMT) has partnered with Dr. Danny Chou of Compassion BioSolution, LLC and other researchers on a multi-collaborator study involving various measurement techniques, including APMT’s ARGEN product. Dr. Chou will present the results of this study on August 15-16, 2016 at the Bioprocessing Summit in Boston.
The ARGEN instrument utilizes 16 completely independent sample holders, and each is capable of precise control of temperature and stirring stressors applied to the sample solution. ARGEN utilizes Right Angle Static Light Scattering (SLS), which is a standard method for characterizing the size and stability of polymers, proteins and other natural products in solution. ARGEN’s continuous measurement provides direct insight into, and early detection of, the mass aggregation and kinetic determination of the Aggregation Rate (AR) of the sample.
“Working in partnership with pharmaceutical scientists to demonstrate ARGEN’s capabilities in the research and development of biopharmaceuticals has been an extremely fruitful project yielding very interesting results about optimized formulation analysis,” says Michael Drenski, APMT Chief Technical Officer.
The results of the study showed that orthogonal analytical tools like ARGEN, when used in combination with a high-throughput formulation development platform, are an integral part of an effective strategy to uncover the key factors and forces that impact the physical stability of proteins in solution. Details of the study will be published in the American Pharmaceutical Review.
“We are at the dawn of a new era with the emergence of new analytical tools that can enable both prediction and real-time monitoring of protein stability. Thanks to APMT and other research collaborators on this project we were able to combine a DOE-based approach to formulation screening with high throughput analytical tools that can shorten both development time and improve the likelihood of developing a robust formulation. My experience with ARGEN suggests that it is a powerful tool that combines a proven principle for protein aggregate detection (static light scattering) with a design that can enable real-time measurement of aggregation rate under stress conditions (heat and agitation), which are relevant for biopharmaceutical applications. I look forward to continuing this collaboration in order to explore the full potential of this technology,” says Dr. Chou.
Advanced Polymer Monitoring Technologies, Inc. develops, manufactures and distributes products and services for the real time monitoring, analysis, and control of polymer reactions, solutions, dispersions and suspensions across all synthetic and natural polymer sectors from R&D through high volume industrial production. For more information, visit www.apmtinc.com.
About the BioProcessing Summit
The Bioprocessing Summit convenes more than 1,000 international bioprocess professionals to share practical solutions for today’s bioprocess challenges. Now in its eighth year, the event features 16 distinct meetings ranging from cell line development and ensuring quality, to formulation, analytical development, continuous processing, purification, viral clearance and safety, and bioproduction. New programming in 2016 will continue to expand the scope of the event and includes weeklong programming on cell and gene therapy production and a meeting on manufacturing and CMC strategies for biologics. For more information, visit http://www.bioprocessingsummit.com.