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ARGEN
Fluence Analytics - ACS

ACOMP and ARGEN take center stage at 255th ACS National Meeting & Exposition in New Orleans

Fluence Analytics, a manufacturer of realtime monitoring solutions for polymer and biopharmaceutical companies, will present two session talks and have an exhibition booth during the American Chemical Society’s (ACS) 2018 Spring National Meeting & Exposition. The 255th National Meeting is taking place in New Orleans, LA from March 18-22. The first Fluence Analytics presentation will...
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ARGEN

Application Note: ARGEN 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN

Application Note: ARGEN 002

Formulation Development with ARGEN Abstract Formulations are developed in the biopharmaceutical space as a set of solution conditions that lead to the highest stability of a therapeutic substance such as an antibody protein or peptide.  The solution conditions that generally affect the stability of the solute are solvent choice, ionic strength, pH, excipient, surfactant and...
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ARGEN

Application Note: ARGEN 001

Comparing the Stability of Protein Formulations with ARGEN Abstract Because ARGEN’s 16 experiments are fully independent, users can determine aggregation or degradation characteristics of protein formulations for all samples simultaneously, regardless of their individual time spans (some can take minutes, others can take weeks). When one sample is complete, another can immediately take its place....
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ARGEN Webinar

Webinar: Introduction to ARGEN

Rapid Analysis of Protein Formulation Stability ARGEN, by Fluence Analytics, adds another powerful tool to the protein scientist’s arsenal. ARGEN is a light scattering instrument with 16 independent sample cells that can simultaneously test for protein aggregation utilizing light scattering while stressing samples under multiple conditions including chemical, mechanical and thermal…all in real time and...
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ARGEN

Automated & Rapid Way to Asses Quality & Stability of Biologics

This peer review article from American Pharmaceutical Review describes new tools, including ARGEN by Fluence Analytics, that not only have low sample requirements but also generate precise and reproducible data to effectively implement an advanced design of experiments approach. This article uses a real case study using an IgG 1 antibody to illustrate how to properly...
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PepTalk logo

Fluence Analytics to exhibit and present new developments in use of light scattering to determine aggregation rates at PepTalk 2018

PepTalk, one of the largest annual conferences for protein researchers in the world, will take place from January 8-12, 2018 at the Hilton San Diego Bayfront. Fluence Analytics is attending the 17th annual conference and will showcase ARGEN at exhibition booth number 315. The booth will feature an ARGEN system with software demos, and members of...
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ARGEN

Technical Note: ARGEN 002

Generating Aggregation Rates to Determine Stability of Monoclonal Antibodies Background Static light scattering is widely used to measure the molar masses of molecules, particles and their aggregates under various solution conditions and compositions1. The ARGEN instrument has the capability to run 16 independent light scattering experiments simultaneously. It can monitor the change in both absolute...
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ARGEN

Technical Note: ARGEN 001

ARGEN: The Aggregation Rate GENerator that monitors protein and polymer stability Summary Fluence Analytics ARGEN platform continuously measures the light scattering from 16 independent solutions to assess the pharmaceutical stability of therapeutic proteins and natural polymers. ARGEN applies temperature and stirring stressors independently to each of the 16 sample cells, replicating the conditions of and...
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ARGEN

ARGEN Brochure

Protein Stability Monitoring ARGEN by Fluence Analytics is the right instrument to assess the pharmaceutical stability of therapeutic proteins and general stability of natural polymer products. ARGEN allows for 16 independent experiments to run simultaneously, and each sample is measured continuously throughout the experiment, yielding extremely valuable kinetic sample stability data. ARGEN utilizes 16 completely independent cuvette sample holders, and...
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