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ARGEN
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Reproducibility of Thermally Induced and Contact-stir Induced Protein Aggregation

This peer-reviewed publication by Fluence Analytics’ research partner Tulane PolyRMC addresses the reproducibility of protein aggregation. The publication, which appears in the Journal of Physical Chemistry, specifically discusses reproducibility following temperature-induced and contact-stir induced aggregation of bovine serum albumin and a monoclonal antibody. Using ARGEN, PolyRMC assessed protein aggregation reproducibility for global stressors which affect an...
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Technical Bulletin – FATB0918

The third edition of the Fluence Analytics Technical Bulletin Series includes an ACOMP case history and a technical note on using ARGEN to analyze the impact of stirring stress.
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ARGEN_PEGS Boston 2018

Impact of Stirring Stress: ARGEN Technical Note 004

Using ARGEN to Determine the Impact of Mechanical and Physical Stress   Curt Jarand, Ph.D. Tulane University Center for Polymer Reaction Monitoring and Characterization (PolyRMC) New Orleans, LA 70118   The Stirring Problem: There is intense interest among therapeutic protein researchers about factors which impact protein aggregation and stability. Aggregation of therapeutic proteins can render...
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ARGEN_PEGS Boston 2018

Using 90° SLS to Determine Mw: ARGEN Technical Note 003

On the limits of 90° static light scattering for determining weight average molar mass Mw – A discussion with Chief Science Officer, Dr. Wayne Reed Technical Note 003 assesses the fractional error in Mw that results when θ=90° detection is used, instead of a full angular extrapolation via MALS.   Question: Can you compare the differences in...
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ARGEN_PEGS Boston 2018

Formulating Four Peptides: ARGEN Application Note 005

Formulation of Four Peptide Solutions in 15 Days Background Custom designed oligopeptides are an increasingly accessible option in peptide-based technologies for pharmaceuticals. Following their synthesis, peptides are often subjected to HPLC purification and synthetic modification, which can require the use of non-aqueous media or salts requiring later removal. During the production of pharmaceutical peptides, spoilage...
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Webinar: Benefits of In Situ Aggregation Kinetics with ARGEN

Explore the advantages of In Situ Aggregation Kinetics with ARGEN!   Chris Roberts, Professor at the University of Delaware (UD), explores the benefits of using in situ aggregation kinetics during this webinar which includes data collected on an ARGEN, a static light scattering instrument. The webinar also incorporates the presentation of two case studies where ARGEN...
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Fluence Analytics Brochure

Fluence Analytics Brochure: realtime data. realtime optimization. Fluence Analytics is a manufacturer of industrial and laboratory monitoring solutions that produce continuous data streams. The company has two product lines, ACOMP and ARGEN. Combined with powerful, proprietary analytical tools, the confluence of data from the company’s measurements enable realtime optimization leading to improved process control and faster R&D for polymer and biopharmaceutical manufacturers....
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ARGEN_PEGS Boston 2018

Kinetic Analysis of Peptide Aggregation: ARGEN Application Note 004

Kinetic Analysis of Peptide Aggregation Background Peptide-based pharmaceutical technology requires the delivery of therapeutic oligopeptides as designed in a stable form for effective application. Downstream from therapeutic peptide isolation or synthesis, peptides are often subjected to HPLC purification, synthetic modification, and preparatory treatments for long-term storage. Spoilage in the form of aggregation, degradation or oxidation...
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Fluence Analytics to exhibit at PEGS Boston: The Essential Protein Engineering Summit

  PEGS: The Essential Protein Engineering Summit is one  of the industry’s preeminent events for anyone involved in biotherapeutic drug development. The annual conference is always held in Boston, and this year’s summit will take place at the Seaport World Trade Center from April 30 – May 4. At booth number 438, Fluence Analytics will...
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Webinar: Intro to Light Scattering by Dr. Wayne Reed

 Interested in learning about the fundamentals of Light Scattering? Want to know more about the differences between DLS and SLS?   Watch the free webinar by Fluence Analytics CSO, Dr. Wayne Reed, who provides an introduction to light scattering then discusses how the technique’s use as a characterization tool has evolved with the growing needs of...
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