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ARGEN
ARGEN_PEGS Boston 2018

Technical Note: ARGEN 004

Using ARGEN to Determine the Impact of Mechanical and Physical Stress   Curt Jarand, Ph.D. Tulane University Center for Polymer Reaction Monitoring and Characterization (PolyRMC) New Orleans, LA 70118   The Stirring Problem: There is intense interest among therapeutic protein researchers about factors which impact protein aggregation and stability. Aggregation of therapeutic proteins can render...
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ARGEN_PEGS Boston 2018

Technical Note: ARGEN 003

On the limits of 90° static light scattering for determining weight average molar mass Mw – A discussion with Chief Science Officer, Dr. Wayne Reed Technical Note 003 assesses the fractional error in Mw that results when θ=90° detection is used, instead of a full angular extrapolation via MALS.   Question: Can you compare the differences in...
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Fluence Analytics - New website

Fluence Analytics Brochure

Fluence Analytics Brochure: realtime data. realtime optimization. Fluence Analytics is a manufacturer of industrial and laboratory monitoring solutions that produce continuous data streams. The company has two product lines, ACOMP and ARGEN. Combined with powerful, proprietary analytical tools, the confluence of data from the company’s measurements enable realtime optimization leading to improved process control and faster R&D for polymer and biopharmaceutical manufacturers....
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 004

Kinetic Analysis of Peptide Aggregation Background Peptide-based pharmaceutical technology requires the delivery of therapeutic oligopeptides as designed in a stable form for effective application. Downstream from therapeutic peptide isolation or synthesis, peptides are often subjected to HPLC purification, synthetic modification, and preparatory treatments for long-term storage. Spoilage in the form of aggregation, degradation or oxidation...
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Pegs Boston Fluence Analytics

Fluence Analytics to exhibit at PEGS Boston: The Essential Protein Engineering Summit

  PEGS: The Essential Protein Engineering Summit is one  of the industry’s preeminent events for anyone involved in biotherapeutic drug development. The annual conference is always held in Boston, and this year’s summit will take place at the Seaport World Trade Center from April 30 – May 4. At booth number 438, Fluence Analytics will...
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Webinar: Intro to Light Scattering by Dr. Wayne Reed

 Interested in learning about the fundamentals of Light Scattering? Want to know more about the differences between DLS and SLS?   Watch the free webinar by Fluence Analytics CSO, Dr. Wayne Reed, who provides an introduction to light scattering then discusses how the technique’s use as a characterization tool has evolved with the growing needs of...
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ACOMP and ARGEN take center stage at 255th ACS National Meeting & Exposition in New Orleans

Fluence Analytics, a manufacturer of realtime monitoring solutions for polymer and biopharmaceutical companies, will present two session talks and have an exhibition booth (#1111) during the American Chemical Society’s (ACS) 2018 Spring National Meeting & Exposition. The 255th National Meeting is taking place in New Orleans, LA from March 18-22. The first Fluence Analytics presentation...
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN_PEGS Boston 2018

Application Note: ARGEN 002

Formulation Development with ARGEN Abstract Formulations are developed in the biopharmaceutical space as a set of solution conditions that lead to the highest stability of a therapeutic substance such as an antibody protein or peptide.  The solution conditions that generally affect the stability of the solute are solvent choice, ionic strength, pH, excipient, surfactant and...
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FA_Product_ARGEN

Application Note: ARGEN 001

Comparing the Stability of Protein Formulations with ARGEN Abstract Because ARGEN’s 16 experiments are fully independent, users can determine aggregation or degradation characteristics of protein formulations for all samples simultaneously, regardless of their individual time spans (some can take minutes, others can take weeks). When one sample is complete, another can immediately take its place....
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