In this case study, ARGEN was used to determine the effect of protein concentration on the aggregation propensity of bovine serum albumin under stirring stress.Read More
These rAAV capsid stability experiments investigated and monitored the solution behavior of full and empty capsids under thermal stress using ARGEN. ARGEN is uniquely suitable for in situ and real-time characterization of solution stability of larger species such as rAAVs and LNP-RNA complexes. This case study demonstrates ARGEN's ability to elucidate differences in full and...Read More
The ARGEN Digital Booklet provides insight into various applications utilizing ARGEN’s patented simultaneous multiple sample light scattering (SMSLS) technology to accelerate and optimize the development of novel biotherapeutics. Biopharmaceutical companies are experiencing greater demand to develop novel biologic therapeutics in less time, and this requires a paradigm shift in the way teams approach formulation development...Read More
ARBRE MOBIEU 2019 Conference – Booth 10 The 2019 meeting of ARBRE MOBIEU, the Association of Resources for Biophysical Research in Europe — Molecular Biophysics in Europe, is taking place in Zagreb, Croatia from March 18 – 20. At booth number 10, Fluence Analytics will showcase ARGEN, a static light scattering instrument for analyzing molecular aggregation...Read More
This peer-reviewed publication by Fluence Analytics’ research partner Tulane PolyRMC addresses the reproducibility of protein aggregation. The publication, which appears in the Journal of Physical Chemistry, specifically discusses reproducibility following temperature-induced and contact-stir induced aggregation of bovine serum albumin and a monoclonal antibody. Using ARGEN, PolyRMC assessed protein aggregation reproducibility for global stressors which affect an...Read More
The successful development of biotherapeutics requires an in-depth understanding of the impacts associated with mechanical and physical stress. Instability and subsequent aggregation can render them biologically inactive or even induce an immunological response in patients. Stirring stress is one of the most notable factors which disrupts native biopolymer structure and promotes aggregation. However, contact stirring...Read More
On the limits of 90° static light scattering for determining weight average molar mass Mw A discussion with Chief Science Officer, Dr. Wayne Reed This Technical Note assesses the fractional error in Mw that results when θ=90° static light scattering detection is used, instead of a full angular extrapolation via MALS. Read More
Explore the advantages of In Situ Aggregation Kinetics with ARGEN! Chris Roberts, a Professor at the University of Delaware (UD), explores the benefits of using in situ aggregation kinetics during this webinar which includes data collected on an ARGEN, a static light scattering instrument. The webinar also incorporates the presentation of two case studies where...Read More
Fluence Analytics Brochure: realtime data. realtime optimization. Fluence Analytics is a manufacturer of industrial and laboratory monitoring solutions that produce continuous data streams. The company has two product lines, ACOMP and ARGEN. Combined with powerful, proprietary analytical tools, the confluence of data from the company’s measurements enable realtime optimization leading to improved process control and...Read More
PEGS: The Essential Protein Engineering Summit is one of the industry’s preeminent events for anyone involved in biotherapeutic drug development. The annual conference is always held in Boston, and this year’s summit will take place at the Seaport World Trade Center from April 30 – May 4. At booth number 438, Fluence Analytics will...Read More
