Interested in learning about the fundamentals of Light Scattering? Want to know more about the differences between DLS and SLS? Watch the free webinar by Fluence Analytics CSO, Dr. Wayne Reed, who provides an introduction to light scattering then discusses how the technique’s use as a characterization tool has evolved with the growing needs of the...Read More
Colloidal stability is determined by the balance of repulsive and attractive intermolecular interactions between protein molecules, like a monoclonal antibody, to conserve the native folded state. Simply stated, the propensity for aggregation is reduced by less intermolecular interaction. Therefore, determination of the second virial coefficient (B22) is a valuable screening tool to predict aggregation propensity....Read More
These experiments demonstrate the utility of ARGEN™ to define oligomeric states and transitions of Human Insulin under thermal stress. Time to dimerization and time to tetramerization measurements permitted the characterization of a stable dimer species, as well as insights into the mechanisms and kinetics of higher order oligomer formation. Whereas, SEC allows the characterization of...Read More
Rapid Analysis of Protein Formulation Stability ARGEN, by Fluence Analytics, adds another powerful tool to the protein scientist’s arsenal. ARGEN is a light scattering instrument with 16 independent sample cells that can test for protein aggregation while stressing samples under multiple conditions including chemical, mechanical and thermal…all in real time and accelerating protein formulation stability!...Read More
Determine the Stability of Biologics This peer review article from American Pharmaceutical Review describes new tools for determining the stability of biologics, including ARGEN by Fluence Analytics, that not only have low sample requirements but also generate precise and reproducible data to effectively implement an advanced design of experiments approach. This article uses a real case...Read More
PepTalk, one of the largest annual conferences for protein researchers in the world, will take place from January 8-12, 2018 at the Hilton San Diego Bayfront. Fluence Analytics is attending the 17th annual conference and will showcase ARGEN at exhibition booth number 315. The booth will feature an ARGEN system with software demos, and members of...Read More
In these experiments, ARGEN was used to characterize the thermal and chemical stability of a monoclonal antibody and subsequently establish quantitative and qualitative properties such as pH and temperature dependence on aggregation kinetics. Additionally, SEC elution profiles were superimposed onto Mw/Mo output, providing a robust comparison and identification of the stability landscape for the mAb....Read More
Understanding the thermal, chemical and mechanical stability and physical properties of polymers is essential for development success. The case studies below outline the experimental methodologies and data analysis using ARGEN™ to monitor polymer degradation and to characterize molecular weight as well as the effects of temperature, shear stress and solution conditions on the stability of...Read More
ARGEN Brochure: Protein Stability Monitoring ARGEN by Fluence Analytics is the right instrument to assess the stability of therapeutic biopolymers and natural polymer products. ARGEN users can conduct up to 16 independent experiments simultaneously. ARGEN generates real-time, continuous data throughout each experiment, yielding extremely valuable kinetic sample stability data. ARGEN’s 16 cuvette sample holders are...Read More
New Instrument Continuously Analyzes Protein and Natural Polymer Aggregation (New Orleans, LA, U.S.) ‒ Fluence Analytics, a manufacturer of realtime, industrial and laboratory monitoring systems, today announced the launch of ARGEN, a patented protein and polymer stability monitoring product. By utilizing continuous light scattering measurements, ARGEN yields a unique information stream which reduces discovery and...Read More
