Tag

mAb
ARGEN_PEGS Boston 2018

Determining Mw and B22 of mAbs: ARGEN Application Note 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ARGEN_PEGS Boston 2018

Generating Aggregation Rates: ARGEN Technical Note 002

Generating Aggregation Rates to Determine Stability of Monoclonal Antibodies Background Static light scattering is widely used to measure the molar masses of molecules, particles and their aggregates under various solution conditions and compositions1. The ARGEN instrument has the capability to run 16 independent light scattering experiments simultaneously. It can monitor the change in both absolute...
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