Tag

molecular weight
ARGEN_PEGS Boston 2018

Using 90° SLS to Determine Mw: ARGEN Technical Note 003

On the limits of 90° static light scattering for determining weight average molar mass Mw – A discussion with Chief Science Officer, Dr. Wayne Reed Technical Note 003 assesses the fractional error in Mw that results when θ=90° detection is used, instead of a full angular extrapolation via MALS.   Question: Can you compare the differences in...
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ARGEN_PEGS Boston 2018

Kinetic Analysis of Peptide Aggregation: ARGEN Application Note 004

Kinetic Analysis of Peptide Aggregation Background Peptide-based pharmaceutical technology requires the delivery of therapeutic oligopeptides as designed in a stable form for effective application. Downstream from therapeutic peptide isolation or synthesis, peptides are often subjected to HPLC purification, synthetic modification, and preparatory treatments for long-term storage. Spoilage in the form of aggregation, degradation or oxidation...
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ACOMP

Automatic Control of Polymer Composition and Mw

Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Polymer Journal which describes the achievement of fully automatic, simultaneous control of polymer composition and molecular weight trajectories during free radical copolymer synthesis. This was accomplished by coupling the continuous ACOMP data stream into a feedback controller which operated pumps for...
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ARGEN_PEGS Boston 2018

Determining Mw and B22 of mAbs: ARGEN Application Note 003

Determining Molecular Weight (Mw) and Second Virial Coefficient (B22) of monoclonal antibodies using ARGEN Abstract Protein aggregation is generally believed to occur as the result of two instability factors—  conformational and colloidal. Conformational stability is the difference in free energy between the folded and unfolded states of a protein. Although not directly measured as a...
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ACOMP

Automatic Synthesis of Multimodal Polymers

Fluence Analytics collaborated with its academic research partner Tulane PolyRMC on a peer review publication in Macromolecular Reaction Engineering. An automatic molecular weight controller is used in semi-batch reactions to produce final polymers that contain distinct subpopulations with different molecular weight distributions (MWD). While blending polymers with different MWD is frequently used to make multimodal polymer products,...
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ACOMP

Automatic Control of Polymer Molecular Weight during Synthesis

Fluence Analytics and its academic research partner Tulane PolyRMC collaborated on a peer review article for Macromolecules which discusses using ACOMP to automatically control polymer molecular weight during synthesis. The continuous record of monomer and polymer concentrations, Cm and Cp, and cumulative weight-average mass, Mw, furnished by automatic continuous online monitoring of polymerization reactions (ACOMP) has been harnessed...
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ACOMP

Monitoring the polymerization of PVP: ACOMP Application Note 001

Monitoring the effect of initiator concentration on molecular weight and intrinsic viscosity of polyvinyl pyrrolidone (PVP) using ACOMP Abstract Automatic Continuous Online Monitoring of Polymerization Reactions (ACOMP) was used to monitor the free radical polymerization of polyvinyl pyrrolidone (PVP) throughout the reaction. Two batch reactions were run at 1.5% and 2.5% initiator concentration to monitor...
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ACOMP

Introduction to ACOMP: Technical Note 001

ACOMP: The Automated System that allows Continuous Realtime Monitoring of Polymerization Reactions Abstract ​ ACOMP (Automatic Continuous Online Monitoring of Polymerization Reactions) is a patented product from Fluence Analytics that continuously monitors and characterizes polymers during polymerization or post-polymerization processing steps of laboratory or industrial scale polymer reactions. Beyond allowing the user to monitor polymerizations...
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AIChE - Automatic control

Automatic Control of Polymer Molecular Weight Results Presented at AIChE 2017 Spring Meeting

APMT Research Engineer Natalie Leonardi is making a presentation on Automatic Control of Polymer Molecular Weight during a Free Radical Polymerization at the 2017 AIChE Spring Meeting and 13th Global Congress on Process Safety. The Spring Meeting is taking place in San Antonio, TX at the Henry B. Gonzalez Convention Center, and Natalie’s talk is...
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ACOMP

APMT Achieves Automatic Control of Polymer Molecular Weight

ACOMP Enables Automated Control of Polymer Properties during Synthesis (New Orleans, LA, U.S.) ‒ Advanced Polymer Monitoring Technologies (APMT) today announced that it has achieved automatic control of polymer molecular weight during synthesis utilizing new capabilities integrated with APMT’s ACOMP product, which monitors polymer properties during polymerization reactions. The results of this collaborative research effort...
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