In this case study, ARGEN was used to determine the effect of protein concentration on the aggregation propensity of bovine serum albumin under stirring stress.Read More
These rAAV capsid stability experiments investigated and monitored the solution behavior of full and empty capsids under thermal stress using ARGEN. ARGEN is uniquely suitable for in situ and real-time characterization of solution stability of larger species such as rAAVs and LNP-RNA complexes. This case study demonstrates ARGEN's ability to elucidate differences in full and...Read More
In this technical note we will demonstrate the use of active feedback control with Lab ACOMP to directly control polymer molecular weight by adjusting the monomer feed into the reactor. By integrating ACOMP with a feedback controller, molecular weight is directly controlled, something previously not possible in polymerizations.Read More
Using ACOMP in an industrial environment allows for improved polymer quality control of production processes and material properties. With the benefit of an online, real-time analysis provided by ACOMP, plant operators can take corrective actions to change QC parameters or even halt the reaction if the product properties are deviating too much.Read More
ACOMP provides a real-time, online analysis of polymerization reactions. This technical note describes how ACOMP can track the properties of polyacrylamide produced with different initiator types and concentrations. This note compares the effects of initiator type and concentration in the synthesis of polyacrylamide, a specialty polymer with many industrial applications.Read More
This technical note demonstrates the use of ACOMP to monitor two types of polyurethane polymerizations, the industry standard and a novel type using a non-toxic isocyanate monomer. The ACOMP system can monitor in real time the intrinsic viscosity and molecular weight for the stepwise polymerization reaction that occurs.Read More
ACOMP was used to continuously measure the anionic polymerization of solution styrene butadiene rubber. ACOMP successfully tracked conversion, along with weight-average molecular weight (Mw), and low and high shear reduced viscosities (RV), including during the coupling reaction.Read More
This technical note describes the use of ACOMP to monitor polymerization kinetics, intrinsic viscosity and Mw in a very common system for producing pressure sensitive adhesives, which uses the acrylic comonomers acrylic acid (AA) and 2-ethylhexyl acrylate (2EHA).Read More
The successful development of biotherapeutics requires an in-depth understanding of the impacts associated with mechanical and physical stress. Instability and subsequent aggregation can render them biologically inactive or even induce an immunological response in patients. Stirring stress is one of the most notable factors which disrupts native biopolymer structure and promotes aggregation. However, contact stirring...Read More
On the limits of 90° static light scattering for determining weight average molar mass Mw A discussion with Chief Science Officer, Dr. Wayne Reed This Technical Note assesses the fractional error in Mw that results when θ=90° static light scattering detection is used, instead of a full angular extrapolation via MALS. Read More
