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Technical Bulletin – FATB0218

July 10, 2018

This installment of the Fluence Analytics Technical Bulletin Series includes our ACOMP Application Note – Monitoring the Polymerization of Methyl Methacrylate (MMA) and ARGEN Application Note – Formulation Development with ARGEN.

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Technical Bulletin: ACOMP

Application Note – Monitoring the Polymerization of Methyl Methacrylate (MMA)
ACOMP successfully monitored and characterized the solution polymerization of polymethyl methacrylate (PMMA) with and without crosslinker. PMMA is a highly transparent and weatherable polymer that is used as a lighter, more impact resistant alternative to glass. PMMA applications include shatter resistant panels for windows, bathtubs, LCD screens, paints, coatings and various medical and dental applications. Read the full application note here.

Publication – Automatic, Simultaneous Control of Polymer Composition and Molecular Weight
Fluence Analytics and its academic research partner, Tulane-PolyRMC, collaborated on a peer-reviewed publication for Polymer Journal. The publication describes the achievement of fully automatic, simultaneous control of polymer composition and molecular weight trajectories during a free radical copolymerization. This was accomplished by coupling the continuous ACOMP data stream into a feedback controller which operated pumps for reactor feed of comonomers. Read more here.

Technical Bulletin: ARGEN

Application Note – Formulation Development with ARGEN
Since many current techniques do not monitor aggregation as a kinetic process, researchers must prepare a matrix of samples that have varying formulation conditions, place these samples into a long-term storage incubator, and then wait for extended periods of time to determine if aggregates have formed to a detectable level. ARGEN provides this information and allows for the independent and realtime testing of up to 16 simultaneous samples. Read the full application note here.

Application Note – Determining Mw and Second Virial Coefficient of Monoclonal Antibodies
Many publications have concluded that understanding the osmotic interaction of second virial coefficient (B22) is a valuable screening tool for predicting the aggregation propensity of proteins in a formulation state. This application note describes the method in which ARGEN is used to characterize B22 and the approximate weight average molecular weight for a monoclonal antibody. Read the full application note here.

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