This installment of the Fluence Analytics Technical Bulletin Series includes our ACOMP Application Note – Monitoring the Polymerization of Methyl Methacrylate (MMA) and ARGEN Application Note – Formulation Development with ARGEN.
Publication – Automatic, Simultaneous Control of Polymer Composition and Molecular Weight
Fluence Analytics and its academic research partner, Tulane-PolyRMC, collaborated on a peer-reviewed publication for Polymer Journal. The publication describes the achievement of fully automatic, simultaneous control of polymer composition and molecular weight trajectories during a free radical copolymerization. This was accomplished by coupling the continuous ACOMP data stream into a feedback controller which operated pumps for reactor feed of comonomers. Read more here.
Application Note – Determining Mw and Second Virial Coefficient of Monoclonal Antibodies
Many publications have concluded that understanding the osmotic interaction of second virial coefficient (B22) is a valuable screening tool for predicting the aggregation propensity of proteins in a formulation state. This application note describes the method in which ARGEN is used to characterize B22 and the approximate weight average molecular weight for a monoclonal antibody. Read the full application note here.