This dynamic webinar will offer insights into characterizing the stability of an engineered adeno-associated virus (AAV) serotype under moderate thermal stress and physiological solution conditions using light scattering measurements. While AAVs are leading vector systems for gene therapy, significant gaps remain in the understanding of instability and subsequent ejection of DNA from AAV capsids resulting from various forms of thermal, chemical and mechanical stress.

This webinar will present data characterizing the kinetics and effects of thermally-induced perturbations over a range of temperatures on DNA ejection from a full AAV vector. In contrast, empty AAV vectors showed immediate colloidal aggregation due to thermally induced perturbations. Seeding empty vectors with full AAV vectors led to the stabilization of the former. This is an indication of the potential role of DNA in maintaining capsid architecture and preventing capsid protein aggregation.

Defining quantitative and qualitative properties of viral vector systems is critical to ensure maximum efficacy and stability during processing, storage,  and administration. Click on the button below to register for this exciting webinar that will provide key implications toward optimizing the efficacy and storage conditions of adeno-associated virus pharmaceuticals. All registrants will also receive a recording of the live webinar after the event.

Register Now

Meet the Speaker: Prof. Wayne Reed